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The effects of Monosodium glutamate (MSG), a popular food additive, on hematopoietic and cardiovascular risk variables in animal have not been reported till date. We report here the effects of MSG on the said variables in rat model. Adult female rats of Charles foster strain weighing about 100-120 gms were administrated MSG at a dose level of 0.8gm/kg/day, 1.6gm/kg/day, 2.4gm/kg/day, respectively for 30 days. It has been seen that the mean body weight increases significantly in the entire MSG treated groups in a dose dependent manner, and the absolute and relative organ weights of ovary, uterus, heart and liver increases significantly in MSG treated groups of rats in comparison with control rats. We found significant decrease in red blood cell (RBC) and white blood cell (WBC) counts, and hemoglobin concentration in peripheral whole blood in MSG treated groups of rats. Further we found significant increase in the concentration of serum total glucose, protein, cholesterol, triglycerides, very low density lipoprotein (VLDL), glycerol free triglycerides and low density lipoprotein (LDL); and decrease in high density lipoprotein (HDL) in a dose dependent manner in MSG treated rats. From the study we may conclude that MSG suppresses the physiologic functions of the organ systems presumably by reducing the availability of oxygen in tissues through inhibiting the erythropoiesis process for the formation of RBC; by suppressing the cell mediated immunity through reducing the formation of WBC; and by increasing the production of cardiovascular risk metabolites under the influence of hypothalamic pathways emanating from the hunger and satiety nuclei.